KbNB142-70isaninhibitorofPKDthatisusedtostudyPKDactivityinresearchmodels.KbNB142-70preventsangiotensinII-inducedphosphorylationofhistonedeacetylasesandincreasesactivationofAktinintestinalepithelialcells.Thiscompoundmayalsoinhibitmigrationofintestinalepithelialcells.
| CasNo. | 1233533-04-4 |
|---|---|
| Purity | ≥98% |
| Formula | C11H9NO2S2 |
| FormulaWt. | 251.32 |
| IUPACName | 9-Hydroxy-3,4-dihydro[1]benzothieno[2,3-f][1,4]thiazepin-5(2H)-one |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | K0652InfoSheetPDF |
|---|
Sinnett-SmithJ,NiY,WangJ,etal.ProteinkinaseD1mediatesclassIIahistonedeacetylasephosphorylationandnuclearextrusioninintestinalepithelialcells:roleinmitogenicsignaling.AmJPhysiolCellPhysiol.2014May15;306(10):C961-71.PMID:24647541.
NiY,Sinnett-SmithJ,YoungSH,etal.PKD1mediatesnegativefeedbackofPI3K/AktactivationinresponsetoGprotein-coupledreceptors.PLoSOne.2013Sep9;8(9):e73149.Erratumin:PLoSOne.2014;9(1).PMID:24039875.
YoungSH,RozengurtN,Sinnett-SmithJ,etal.RapidproteinkinaseD1signalingpromotesmigrationofintestinalepithelialcells.AmJPhysiolGastrointestLiverPhysiol.2012Aug1;303(3):G356-66.PMID:22595992.
