MevastatinisanHMG-CoAreductaseinhibitorthatexhibitsanti-hyperlipidemic,anticancer,andimmunomodulatoryactivities.Mevastatininducesapoptosisandinhibitsgrowthofsalivaryadenoidcysticcarcinomacellsbyincreasingcytochromecrelease,activationofcaspase3,andphosphorylationofJNK,p38MAPK,andERK1/2.Inothermodels,mevastatininhibitsbisphosphonate-inducedactivationofγδTcellsandreleaseofTNF-α.
| CasNo. | 73573-88-3 |
|---|---|
| Purity | ≥98% |
| Formula | C23H34O5 |
| FormulaWt. | 390.51 |
| ChemicalName | (2S)-2-Methylbutanoicacid(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenylester |
| IUPACName | [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl](2S)-2-methylbutanoate |
| Synonym | Compactin;6-demethylmevinolin;CS-500;ML-236B. |
| MeltingPoint | 152°C |
| Solubility | SolubleinDMSO,orethanol.Insolubleinwater. |
| Appearance | WhitePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1685InfoSheetPDF |
|---|---|
| Brochures | StatinsFlyer |
ZhangS,WangXL,GanYH,etal.Activationofc-JunN-terminalkinaseisrequiredformevastatin-inducedapoptosisofsalivaryadenoidcysticcarcinomacells.AnticancerDrugs.2010Aug;21(7):678-86.PMID:20629200.
ThompsonK,RogersMJ.Statinspreventbisphosphonate-inducedgamma,delta-T-cellproliferationandactivationinvitro.JBoneMinerRes.2004Feb;19(2):278-88.PMID:14969398.
EndoA,KurodaM,TsujitaY.ML-236A,ML-236B,andML-236C,newinhibitorsofcholesterogenesisproducedbyPenicilliumcitrinium.JAntibiot(Tokyo).1976Dec;29(12):1346-8.PMID:1010803.
