LKT/MEVINOLIN/M1687/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/MEVINOLIN/M1687/100 mg

LKT/MEVINOLIN/M1687/100 mg

商品编号： M1687-100mg

品牌： lktlabs

市场价： ¥3300.00

美元价： 1980.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID M1687

Cas No. 75330-75-5

Purity ≥97%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Mevinolin (lovastatin) is a synthetic statin that is also produced by oyster mushrooms and some varieties of rice. Lovastatin inhibits HMG-CoA reductase, preventing cholesterol synthesis; it exhibits anti-hyperlipidemic, anticancer, and antiviral activities. In vitro, lovastatin inhibits proliferation of lymphoma cells, decreasing expression of ROS and transient receptor potential canonical 6 (TRPC6) channels. Additionally, lovastatin inhibits coxsackievirus replication, decreasing expression of coxsackie and adenovirus receptors and preventing viral entry.

Product Info

Cas No.	75330-75-5
Purity	≥97%
Formula	C₂₄H₃₆O₅
Formula Wt.	404.54
Chemical Name	(2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,- 8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalen- yl ester
IUPAC Name	[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Synonym	Mevacor; MK-803; Lovalip; Mevinacor; Mevlor; Sivlor; Lovastatin
Melting Point	174.5°C
Solubility	Soluble in acetone and chloroform. Slightly soluble in DMSO (8mg/mL),methanol and ethanol(6mg/mL). Insoluble in water.
Appearance	White to off-white crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M1687 MSDS PDF
Info Sheet	M1687 Info Sheet PDF
Brochures	Statins Flyer

References

Song X, Liu BC, Lu XY, et al. Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.
Biochim Biophys Acta. 2014 May;1843(5):894-901. PMID: 24518247.

Werner B, Dittmann S, Funke C, et al. Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells. Inflamm Res. 2014 Apr;63(4):267-76. PMID: 24316867.

Gunde-Cimerman N, Cimerman A. Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. Exp Mycol. 1995 Mar;19(1):1-6. PMID: 7614366.

Alberts AW. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. PMID: 3055919.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂