Milrinoneisaninhibitorofphosphodiesterase3(PDE3)thatexhibitsvasodilatoryactivity;itisclinicallyusedtotreatheartfailure.MilrinoneincreasescAMP,PKAactivation,andCa2+influx,strengtheningcontractility.Milrinonealsoexhibitsanticoagulantactivity,inhibitingplateletaggregationbypreventingCa2+releasefromthedensetubularsystem.
| CasNo. | 78415-72-2 |
|---|---|
| Purity | ≥98% |
| Formula | C12H9N3O |
| FormulaWt. | 211.22 |
| ChemicalName | 5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]-quinoline-7-carboxylicacid |
| IUPACName | 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile |
| Synonym | Corotrope;Milrila |
| MeltingPoint | 264°C |
| Solubility | SolubleinDMSO(>10mg/mL). |
| Appearance | AOff-WhitetoTanCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | M3344MSDSPDF |
|---|---|
| InfoSheet | M3344InfoSheetPDF |
HiramatsuN,KageyamaK.Anti-thromboticeffectofmilrinoneiscausedbyinhibitionofcalciumreleasefromthedensetubularsysteminhumanplatelets.ActaAnaesthesiolScand.2003Jan;47(1):53-7.PMID:12492797.
YanoM,KohnoM,OhkusaT,etal.EffectofmilrinoneonleftventricularrelaxationandCa(2+)uptakefunctionofcardiacsarcoplasmicreticulum.AmJPhysiolHeartCircPhysiol.2000Oct;279(4):H1898-905.PMID:11009478.
