Mivacuriumisanon-depolarizing,reversIBLeneuromuscularjunctionblocker.Mivacuriumactsasananesthetic,inhibitingpre-synapticnicotinicacetylcholinereceptors(nAChRs)inneuronsandmuscle.Mivacuriumexhibitsarapidonsetandshortdurationofaction.Thiscompoundalsodisplaysanti-fibrillatory/anti-arrhythmicactivity,asitsinhibitionofsignalingintheparasympatheticnervoussystempreventsatrialfibrillationinanimalmodels.
| CasNo. | 106861-44-3 |
|---|---|
| Purity | ≥98% |
| Formula | C58H80N2O14Cl2 |
| FormulaWt. | 1100.18 |
| IUPACName | bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl](E)-oct-4-enedioate;dichloride |
| Appearance | Whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M3584InfoSheetPDF |
|---|
PattersonE,LuZ,LinJ,etal.Antifibrillatorypropertiesofmivacuriuminacaninemodelofatrialfibrillation.JCardiovascPharmacol.2008Mar;51(3):293-303.PMID:18356695.
JonssonM,GurleyD,DabrowskiM,etal.Distinctpharmacologicpropertiesofneuromuscularblockingagentsonhumanneuronalnicotinicacetylcholinereceptors:apossibleexplanationforthetrain-of-fourfade.Anesthesiology.2006Sep;105(3):521-33.PMID:16931985.
FeldmanSA,WuX,EnglandA.Rateof"onset"and"offset"offournon-depolarisingneuromuscularblockingdrugs.Anaesthesia.1995Jun;50(6):510-3.PMID:7618664.
