LevosimendanisacalciumsensitizerthatstABIlizestroponinC,activatesATP-sensitiveK+channels,andinhibitsphosphodiesterases(PDEs).Levosimendanisclinicallyusedtotreatheartfailure,asitimprovescardiacperformanceandmyocardialcontractilitywithoutincreasingoxygenconsumptionordecreasingpreloadorafterload.Levosimendanexhibitsvasodilatoryandcardioprotectiveactivities,improvingleftventricularfunctioninanimalmodelsofmyocardialischemia/reperfusion.
| CasNo. | 141505-33-1 |
|---|---|
| Purity | ≥98% |
| Formula | C14H12N6O |
| FormulaWt. | 280.28 |
| ChemicalName | Mesoxalonitrile(-)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazone |
| IUPACName | 2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile |
| Synonym | Simdax |
| MeltingPoint | 210-214°C |
| Solubility | Insolubleinwater(0.04mg/ml),solubleinDMSO(>50mg/ml). |
| Appearance | YellowCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L1884MSDSPDF |
|---|---|
| InfoSheet | L1884InfoSheetPDF |
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