LofexidineisanagoNISTatα2-adrenergicreceptorsthatexhibitsantihypertensiveactivity.Lofexidineiscurrentlyunderexaminationasatreatmentofopioidwithdrawal.Inanimalmodels,lofexidineinhibitsstress-inducedreinstatementandself-administrationofdruguse.
| CasNo. | 21498-08-8 |
|---|---|
| Purity | ≥98% |
| Formula | C11H12Cl2N2O•HCl |
| FormulaWt. | 295.60 |
| ChemicalName | 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazolehydrochloride |
| IUPACName | 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride |
| Synonym | Lofetensin;Loxacor |
| MeltingPoint | 230-232°C |
| Solubility | Solubleinwaterandethanol.Slightlysolublein2-propanol.Practicallyinsolubleinether. |
| Appearance | Whiteoroffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L5822MSDSPDF |
|---|---|
| InfoSheet | L5822InfoSheetPDF |
GowingL,FarrellMF,AliR,etal.Alpha2-adrenergicagonistsforthemanagementofopioidwithdrawal.CochraneDatabaseSystRev.2014Mar31;3:CD002024.PMID:24683051.
LêAD,HardingS,JuzytschW,etal.Roleofalpha-2adrenoceptorsinstress-inducedreinstatementofalcoholseekingandalcoholself-administrationinrats.Psychopharmacology(Berl).2005May;179(2):366-73.PMID:15551068.
