LosartanisaninhibitoroftheangiotensinIItype1(AT1)receptorthatexhibitsantihypertensive,anti-fibrotic,andnephroprotectiveactivities.Inanimalmodelsofobstructivenephropathy,losartandecreaseslevelsofα-SMAandcollagentype1andinhibitsphosphorylationofSTAT3,suppressingrenaltubularfibrosis.Losartanalsoinhibitstheendothelial-to-mesenchymaltransitionthroughindirectinhibitionofERKactivation,potentiallyshowinganti-fibroticbenefitaftermyocardialinfarction.
| CasNo. | 124750-99-8 |
|---|---|
| Purity | ≥98% |
| Formula | C22H22ClN6OK |
| FormulaWt. | 461.01 |
| ChemicalName | 2-Butyl-4-chloro-1-[[2"-(1H-tetrazol-5-yl)[1,1"-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanolmonopotassiumsalt |
| IUPACName | potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
| Synonym | DuPont-753;Losaprex;Lortaan;Neo-Lotan;Oscaar |
| MeltingPoint | 263-265°C |
| Solubility | Solubleinwaterto100mM,DMSOto100mM,andalcohol. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | L5873MSDSPDF |
|---|---|
| InfoSheet | L5873InfoSheetPDF |
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