LKT/Madecasoside/M0113/1克-免疫在线蚂蚁淘旗下平台

商品详细LKT/Madecasoside/M0113/1克

LKT/Madecasoside/M0113/1克

商品编号： M0113-1g

品牌： lktlabs

市场价： ¥24060.00

美元价： 14436.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDM0113

CasNo.34540-22-2

Purity≥90%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

MadecassosideisatriterpenoidfoundinCentellathatexhibitsanti-inflammatory,antioxidative,anti-fibrotic,neuroprotective,andcardioprotectiveactivities.Inanimalmodelsofcerebralischemia/reperfusion,madecassosidedownregulatesexpressionofmalondialdehyde,NO,andpro-inflammatorycytokines,preventsapoptosis,decreasesinfarctsize,andattenuatescognitivedeficits.Madecassosideprotectsneuronsagainstamyloid-β(Aβ)-inducedinflammationandautophagy;italsoshowspotentialbenefitinanimalmodelsofParkinson’sdisease.Additionally,madecassosidedownregulatesexpressionofα-smoothmuscleactinandTGF-β1,attenuatesphosphorylationofSmad2/3,decreasesmyeloperoxidaseactivityandmalondialdehydelevels,andincreasessuperoxidedismutaseandglutathionelevels,amelioratingpulmonaryfibrosis.Thiscompoundalsodecreasesinfarctsize,lowerslevelsoflactatedehydrogenase,malondialdehyde,andcreatinekinase,andsuppressesapoptosis,providingprotectioninmyocardialischemia/reperfusionmodels.

ProductInfo

CasNo.	34540-22-2
Purity	≥90%
Formula	C₄₈H₇₈O₂₀
FormulaWt.	975.12
IUPACName	[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
Appearance	WhitePowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	M0113MSDSPDF
InfoSheet	M0113InfoSheetPDF

References

LuoY,YangYP,LiuJ,etal.Neuroprotectiveeffectsofmadecassosideagainstfocalcerebralischemiareperfusioninjuryinrats.BrainRes.2014May27;1565:37-47.PMID:24735651.

DuB,ZhangZ,LiN.MadecassosidepreventsAβ(25-35)-inducedinflammatoryresponsesandautophagyinneuronalcellsthroughtheclassIIIPI3K/Beclin-1/Bcl-2pathway.IntImmunopharmacol.2014May;20(1):221-8.PMID:24631516.

LuGX,BianDF,JiY,etal.MadecassosideAmelioratesBleomycin-InducedPulmonaryFibrosisinMicebyDownregulatingCollagenDeposition.PhytotherRes.2014Jan23.[Epubaheadofprint].PMID:24458872.

BianGX,LiGG,YangY,etal.Madecassosidereducesischemia-reperfusioninjuryonregionalischemiainducedheartinfarctioninrat.BiolPharmBull.2008Mar;31(3):458-63.PMID:18310910.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂