Description
Mdivi-1isaquinazolinoneinhibitorofmitochondrialdivisionthatpreventsmitochondrialfissionandexhibitsneuroprotective,cardioprotective,andanti-metastaticproperties.Inspinalcordinjurymodels,Mdivi-1decreasesneuronalapoptosisandamelioratesmotordysfunction.Inanimalmodelsofmyocardialinfarction,thiscompounddecreasesoxidativedamage,enhancesmyocardialperformance,andimprovesoverallsurvivalrates.Mdivi-1alsoinhibitshypoxia-inducedmigrationinbreastcancercellsandimprovestheactivityofotherco-admiNISTeredchemotherapeutics.
References
LiG,JiaZ,CaoY,etal.MitochondrialDivisionInhibitor1AmelioratesMitochondrialInjury,Apoptosis,andMotorDysfunctionAfterAcuteSpinalCordInjuryinRats.NeuRochemRes.2015May13.[Epubaheadofprint].PMID:25968480.
LiuJM,YiZ,LiuSZ,etal.Themitochondrialdivisioninhibitormdivi-1attenuatesspinalcordischemia-reperfusioninjurybothinvitroandinvivo:InvolvementofBKchannels.BrainRes.2015Mar24.[Epubaheadofprint].PMID:25818100.
SharpWW,BeiserDG,FangYH,etal.Inhibitionofthemitochondrialfissionproteindynamin-relatedprotein1improvessurvivalinamurinecardiacarrestmodel.CritCareMed.2015Feb;43(2):e38-47.PMID:25599491.
HanXJ,YangZJ,JiangLP,etal.Mitochondrialdynamicsregulateshypoxia-inducedmigrationandantineoplasticactivityofcisplatininbreastcancercells.IntJOncol.2015Feb;46(2):691-700.PMID:25434519.
