CarbimazoleisamethimazoleprodrugthatisclinicallyusedtotreathyperthyroidismandGraves’disease;itexhibitsimmunomodulatoryandanti-thyroidactivities.Carbimazoleinhibitsthyroidperoxidase,decreasingproductionofthyroidhormonesT3andT4.InclinicalsubjectswithGraves’disease,carbimazoleincreaseslevelsofIL-2andfreerADIcalscavengersanddecreaseslevelsofIL-2Rs.
| CasNo. | 22232-54-8 |
|---|---|
| Purity | ≥98% |
| Formula | C7H10N2O2S |
| FormulaWt. | 186.23 |
| ChemicalName | 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylicacidethylester |
| IUPACName | ethyl3-methyl-2-sulfanylideneimidazole-1-carboxylate |
| Synonym | Athyromazole;Neo-mercazole;Neo-Thyreostat |
| MeltingPoint | 122-125°C |
| Solubility | Solubleinwater(500parts),ethanol(50parts),andchloroform(3parts). |
| Appearance | White-almostwhitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C0172InfoSheetPDF |
|---|
MannaD,RoyG,MugeshG.Antithyroiddrugsandtheiranalogues:synthesis,structure,andmechanismofaction.AccChemRes.2013Nov19;46(11):2706-15.PMID:23883148.
WilsonR,McKillopJH,BuchananLM,etal.Theeffectofcarbimazoletherapyoninterleukin2,interleukin2receptorsandfreeradicals.Autoimmunity.1990;8(1):3-7.PMID:2129783.
