ChelerythrineisabenzophenanthridinealkaloidfoundinChelidoniumandZanthoxylumthatexhibitsanti-inflammatoryandanticanceractivities.ChelerythrineinhibitsPKCandNa+/K+ATPases.InLPS-stimulatedanimalmodels,chelerythrinedecreaseslevelsofTNF-α,IL-6,andmyeloperoxidase.Inhepatomacells,thiscompounddecreasesthemitochondrialmembranepotential,increasesreleaseofcytochromeC,stimulatescleavageofPARP,alterstheBax/Bcl-xlratio,andinducesapoptosis.
| CasNo. | 3895-92-9 |
|---|---|
| Purity | ≥98% |
| Formula | C21H18ClNO4 |
| FormulaWt. | 383.82 |
| ChemicalName | 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium |
| IUPACName | 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride |
| Synonym | Toddaline |
| MeltingPoint | 207°C |
| Solubility | SolubleinDMSO. |
| Appearance | YellowPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C2818MSDSPDF |
|---|---|
| InfoSheet | C2818InfoSheetPDF |
NiuX,MuQ,LiW,etal.ProtectiveEffectsofChelerythrineAgainstLipopolysaccharide-InducedEndotoxicShockinMice.Inflammation.2014Jun14.[Epubaheadofprint].PMID:24928629.
DorneyKM,SizemoreIE,AlqahtaniT,etal.Surface-enhancedRamanspectroscopy(SERS)trackingofchelerythrine,aNa(+)/K(+)pumpinhibitor,intocytosolandplasmamembranefractionsofhumanlensepithelialcellcultures.CellPhysiolBiochem.2013;32(7):146-56.PMID:24429821.
ZhangZF,GuoY,ZhangJB,etal.InductionofapoptosisbychelerythrinechloridethroughmitochondrialpathwayandBcl-2familyproteinsinhumanhepatomaSMMC-7721cell.ArchPharmRes.2011May;34(5):791-800.PMID:21656365.
