Description
Chelerythrine is a benzophenanthridine alkaloid found in Chelidonium and Zanthoxylum that exhibits anti-inflammatory and anticancer activities. Chelerythrine inhibits PKC and Na+/K+ ATPases. In LPS-stimulated animal models, chelerythrine decreases levels of TNF-α, IL-6, and myeloperoxidase. In hepatoma cells, this compound decreases the mitochondrial membrane potential, increases release of cytochrome C, stimulates cleavage of PARP, alters the Bax/Bcl-xl ratio, and induces apoptosis.
References
Niu X, Mu Q, Li W, et al. Protective Effects of Chelerythrine Against Lipopolysaccharide-Induced Endotoxic Shock in Mice. Inflammation. 2014 Jun 14. [Epub ahead of print]. PMID: 24928629.
Dorney KM, Sizemore IE, Alqahtani T, et al. Surface-enhanced Raman spectroscopy (SERS) tracking of chelerythrine, a Na(+)/K(+) pump inhibitor, into cytosol and plasma membrane fractions of human lens epithelial cell cultures. Cell Physiol Biochem. 2013;32(7):146-56. PMID: 24429821.
Zhang ZF, Guo Y, Zhang JB, et al. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell. Arch Pharm Res. 2011 May;34(5):791-800. PMID: 21656365.
