ChlorpheniramineisafirstgenerationalkylamineantihistaminethatinhibitsH1histaminereceptors,SEROtonintransporters(SERT),andnorepinephrinetransporters(NET);itexhibitsanti-allergicandantidepressantactivities.Chlorpheniramineisclinicallyusedtotreatallergicrhinitisandurticaria.Inanimalmodels,chlorpheniraminedisplayssomemodulationofmemoryconsolidation.
| CasNo. | 113-92-8 |
|---|---|
| Purity | ≥98% |
| Formula | C16H19ClN2•C4H4O4 |
| FormulaWt. | 390.87 |
| ChemicalName | ψ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridine-propanamineMaleate |
| IUPACName | (Z)-but-2-enedioicacid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine |
| Synonym | Allergisan;Anntagonate;Cloropiril;Histadur;Lorphen;Teldrin |
| MeltingPoint | 130-135°C |
| Solubility | Solubleinwater(250mg/mL)andethanol(100mg/mL). |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C2949InfoSheetPDF |
|---|
GianlorençoAC,SerafimKR,Canto-de-SouzaA,etal.EmotionalmemoryconsolidationimpairmentinducedbyhistamineismediatedbyH1butnotH2receptors.BrainResBull.2012Dec1;89(5-6):197-202.PMID:22986235.
HellbomE.Chlorpheniramine,selectiveserotonin-reuptakeinhibitors(SSRIs)andover-the-counter(OTC)treatment.MedHypotheses.2006;66(4):689-90.PMID:16413139.
