StemRegeninisanimmunostimulatoryantagoNISTatthearylhydrocarbonreceptor(AhR).StemRegenin1increasesdendriticcellproduction,allogenicTcellresponses,andIFN-α,TNF-α,andIL-12expression.IncombinationwithBMP4andPGE2,stemRegenin1inducesdifferentiationandexpressionofinducIBLepluripotentstemcells(iPSCs).
| Purity | ≥98% |
|---|---|
| Formula | C24H23N5OS•0.7HCl•0.2H2O |
| FormulaWt. | 458.7 |
| Synonym | SR1 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S7618InfoSheetPDF |
|---|
ThordardottirS,HangalapuraBN,HuttenT,etal.ThearylhydrocarbonreceptorantagonistStemRegenin1promoteshumanplasmacytoidandmyeloiddendriticcelldevelopmentfromCD34+hematopoieticProgenitorcells.StemCellsDev.2014May1;23(9):955-67.PMID:24325394.
GoriJL,ChandrasekaranD,KowalskiJP,etal.Efficientgeneration,purification,andexpansionofCD34(+)hematopoieticprogenitorcellsfromnonhumanprimate-inducedpluripotentstemcells.Blood.2012Sep27;120(13):e35-44.PMID:22898598.
BoitanoAE,WangJ,RomeoR,etal.Arylhydrocarbonreceptorantagonistspromotetheexpansionofhumanhematopoieticstemcells.Science.2010Sep10;329(5997):1345-8.Erratumin:Science.2011May6;332(6030):664.PMID:20688981.
