LKT/RISPERIDONE/R3475/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/RISPERIDONE/R3475/1 g

LKT/RISPERIDONE/R3475/1 g

商品编号： R3475-1g

品牌： lktlabs

市场价： ¥11560.00

美元价： 6936.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDR3475

CasNo.106266-06-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Risperidoneisabenzisoxazoleatypicalantipsychoticthatalsoexhibitsantidepressant,anti-inflammatory,andneuroprotectiveactivities.RisperidoneactsasanantagoNISTatD2receptorsand5-HT2Areceptorsandasanagonistat5-HT7receptors.Invivo,risperidoneincreasesreleaseofDA,5-HT,andNEinthefrontalcortex.RisperidoneisalsoapartialuncompetitiveinhibitorofD-aminoacidoxidase,whichinhibitsoxidationofD-serine,anNMDAreceptoragonistassociatedwiththeonsetofschizophrenia;risperidonealsoinhibitsD-aminoacid-inducedcelldeathinvitro.Inanimalmodelsofneuroinflammationorencephalitis,risperidoneincreasesexpressionofPPARγanddecreasesLPS-inducedexpressionofTNF-α,IL-1β,COX,p38MAPK,andNF-κB.

ProductInfo

CasNo.	106266-06-2
Purity	≥98%
Formula	C₂₃H₂₇FN₄O₂
FormulaWt.	410.49
ChemicalName	3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one
IUPACName	3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
MeltingPoint	170C
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	R3475MSDSPDF
InfoSheet	R3475InfoSheetPDF

References

KamińskaK,GołembiowskaK,RogóżZ.Effectofrisperidoneonthefluoxetine-inducedchangesinextracellulardopamine,SEROtoninandnoradrenalineintheratfrontalcortex.PharmacolRep.2013;65(5):1144-51.PMID:24399710.

MacDowellKS,García-BuenoB,MadrigalJL,etal.Risperidonenormalizesincreasedinflammatoryparametersandrestoresanti-inflammatorypathwaysinamodelofneuroinflammation.IntJNeuropsychopharmacol.2013Feb;16(1):121-35.PMID:22176740.

KozielskaM,JohnsonM,PillaReddyV,etal.Pharmacokinetic-pharmacodynamicmodelingoftheD2and5-HT(2A)receptoroccupancyofrisperidoneandpaliperidoneinrats.PharmRes.2012Jul;29(7):1932-48.PMID:22437487.

AbouEl-MagdRM,ParkHK,KawazoeT,etal.TheeffectofrisperidoneonD-aminoacidoxidaseactivityasahypothesisforanovelmechanismofactioninthetreatmentofschizophrenia.JPsychopharmacol.2010Jul;24(7):1055-67.PMID:19329549.

TooheyN,KleinMT,KnightJ,etal.Human5-HT7receptor-inducedinactivationofforskolin-stimulatedadenylatecyclasebyrisperidone,9-OH-risperidoneandother"inactivatingantagonists".MolPharmacol.2009Sep;76(3):552-9.PMID:19509219.

PotkinSG,SahaAR,KujawaMJ,etal.Aripiprazole,anantipsychoticwithanovelmechanismofaction,andrisperidonevsplaceboinpatientswithschizophreniaandschizoaffectivedisorder.ArchGenPsychiatry.2003Jul;60(7):681-90.PMID:12860772.

FardeL,NybergS,OxenstiernaG,etal.PositronemissiontomographystudiesonD2and5-HT2receptorbindinginrisperidone-treatedschizophrenicpatients.JClinPsychopharmacol.1995Feb;15(1Suppl1):19S-23S.PMID:7537284.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂