Ritodrineisaβ2-adrenergicreceptoragoNISTthatexhibitstocolyticactivity.Ritodrineisclinicallyusedtopreventpretermlabor,asitdecreasesprostanoidsignalingandinhibitsuterinecontractility.RitodrineactivatesCa2+-activated(SK/BK)K+channelsandATP-sensitiveK+channels,potentiallyunderlyingitssmoothmusclecellrelaxanteffects.Additionally,ritodrinemayinducetheformationofpruriticerythematouspapulareruptionswhenusedclinically.
| CasNo. | 23239-51-2 |
|---|---|
| Purity | ≥98% |
| Formula | C17H21NO3•HCl |
| FormulaWt. | 323.82 |
| IUPACName | 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride |
| Synonym | Ritodrina,Ritodrinium |
| MeltingPoint | 192-196°C |
| Appearance | WhitetoYellowPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R3477InfoSheetPDF |
|---|
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HamadaY,NakayaY,HamadaS,etal.ActivationofK+channelsbyritodrinehydrochlorideinuterinesmoothmusclecellsfrompregnantwomen.EurJPharmacol.1994Dec15;288(1):45-51.PMID:7705467.
DubinNH,GhodgaonkarRB.EffectofritodrinehydrochlorideanddibutyrylcyclicAMPoncontractileactivityandprostanoidproductionofuterifrompregnantratsinvitro.ProstaglandinsLeukotMed.1984Feb;13(2):119-28.PMID:6326162.
