Rofecoxibisanon-steroidalanti-inflammatorydrug(NSAID)thatselectivelyinhibitsCOX-2;itexhibitsanti-inflammatory,analgesic,antiepileptic/anticonvulsant,andchemopreventiveactivitiesbutisnolongerclinicallyadmiNISTered.RofecoxibinhibitstheformationofbladdertumorsinFHITmodelsofbladdercancercarcinogenesis.Additionally,rofecoxibincreasesseizurethresholdinanadenosine-dependentmannerinvivo.
| CasNo. | 162011-90-7 |
|---|---|
| Purity | ≥98% |
| Formula | C17H14O4S |
| FormulaWt. | 314.36 |
| ChemicalName | 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone |
| IUPACName | 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one |
| Synonym | Vioxx |
| MeltingPoint | 207-208°C |
| Solubility | Slightlysolubleinmethanolandacetone.Insolubleinwater. |
| Appearance | Slightlyyellowishpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | R5722MSDSPDF |
|---|---|
| InfoSheet | R5722InfoSheetPDF |
D"ArcaD,LeNoirJ,WildemoreB,etal.PreventionofurinarybladdercancerintheFHITknock-outmousewithRofecoxib,aCox-2inhibitor.UrolOncol.2010Mar-Apr;28(2):189-94.PMID:19372053.
AkulaKK,DhirA,KulkarniSK.Rofecoxib,aselectivecyclooxygenase-2(COX-2)inhibitorincreasespentylenetetrazolseizurethresholdinmice:possIBLeinvolvementofadenosinergicmechanism.EpilepsyRes.2008Jan;78(1):60-70.PMID:18054463.
