RoscovitineisaninhibitorofCDKs(1,2,5,7,9,12)andL-typeCa2+channels;itexhibitsanti-inflammatoryandanticanceractivities.Roscovitineresolvesneutrophil-driveninflammation.InB-celllymphomacells,roscovitineinducescellcyclearrestandapoptosisandinhibitsproliferation.
| CasNo. | 186692-46-6 |
|---|---|
| Purity | ≥98% |
| Formula | C19H26N6O |
| FormulaWt. | 354.45 |
| ChemicalName | 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine |
| IUPACName | DISCONTINUED |
| Synonym | Seliciclib,CYC202 |
| MeltingPoint | 106-109°C |
| Solubility | SolubleinDMSOorchloroform. |
| Appearance | Whitecrystallinesolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | R5774MSDSPDF |
|---|---|
| InfoSheet | R5774InfoSheetPDF |
LeitchAE,HaslettC,RossiAG.Cyclin-dependentkinaseinhibitordrugsaspotentialnovelanti-inflammatoryandpro-resolutionagents.BrJPharmacol.2009Oct;158(4):1004-16.PMID:19775281.
YarotskyyV,ElmslieKS.Roscovitine,acyclin-dependentkinaseinhibitor,affectsseveralgatingmechanismstoinhibitcardiacL-type(Ca(V)1.2)calciumchannels.BrJPharmacol.2007Oct;152(3):386-95.PMID:17700718.
LacrimaK,RinaldiA,VignatiS,etal.Cyclin-dependentkinaseinhibitorseliciclibshowsinvitroactivityindiffuselargeB-celllymphomas.LeukLymphoma.2007Jan;48(1):158-67.PMID:17325859.
