LKT/INDINAVIR SULFATE/I5313/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/INDINAVIR SULFATE/I5313/5 g

LKT/INDINAVIR SULFATE/I5313/5 g

商品编号： I5313-5g

品牌： lktlabs

市场价： ¥2460.00

美元价： 1476.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDI5313

CasNo.157810-81-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

IndinavirisanantiviraldrugthattreatsHIV,actingasaproteaseinhibitor;thiscompoundalsoexhibitsanti-diabeticandanticancerchemotherapeuticactivities.Likeotherantivirals,indinaviralsoexertseffectsoninsulinresistanceandglucosetolerance.Invitro,indinavirdecreasesphosphorylationoftheinsulinreceptorβsubunit,inhibitstheGLUT4glucosetransporter,anddecreaseslevelsoftheinsulinreceptor,sterolregulatoryelementbindingprotein1(SREBP1),andPPAR-γ,impairingADIpocytefunctionandalteringinsulinsensitivity.Indiabeticrats,indinavirincreasesglucosetoleranceandhyperglycemia,potentiallythoughinductionofthesuppressorofcytokinesignaling1(SOCS1)signalingcascade.Indinavirmayalsoexhibitchemotherapeuticpotential,asitinhibitsadenocarcinomatumorgrowthinvivo;thisactivitymaybedependentoninhibitionofmatrixmetalloproteinases.Additionally,indinavirinhibitsmultipleisotypesofcalpain,preventingapoptosisincellularmodels.

ProductInfo

CasNo.	157810-81-6
Purity	≥98%
Formula	C₃₆H₄₇N₅O₄•H₂O₄S
FormulaWt.	711.87
IUPACName	(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide;sulfuricacid
Synonym	Crixivan
Solubility	SolubleinWater
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	I5313InfoSheetPDF
Brochures	AntiviralsBooklet

References

IsmailWI,KingJA,AnwarK,etal.Indinavirandnelfinavirinhibitproximalinsulinreceptorsignalingandsalicylateabrogatesinhibition:potentialroleoftheNFkappaBpathway.JCellBiochem.2013Aug;114(8):1729-37.PMID:23386514.

ToschiE,SgadariC,MalavasiL,etal.Humanimmunodeficiencyvirusproteaseinhibitorsreducethegrowthofhumantumorsviaaproteasome-independentblockofangiogenesisandmatrixmetalloproteinases.IntJCancer.2011Jan1;128(1):82-93.PMID:20617515.

CarperMJ,CadeWT,CamM,etal.HIV-proteaseinhibitorsinduceexpressionofsuppressorofcytokinesignaling-1ininsulin-sensitivetissuesandpromoteinsulinresistanceandtype2diabetesmellitus.AmJPhysiolEndocrinolMetab.2008Mar;294(3):E558-67.PMID:18171911.

GhibelliL,MengoniF,LichtnerM,etal.Anti-apoptoticeffectofHIVproteaseinhibitorsviadirectinhibitionofcalpain.BiochemPharmacol.2003Oct15;66(8):1505-12.PMID:14555228.

MurataH,HruzPW,MuecklerM.IndinavirinhibitstheglucosetransporterisoformGlut4atphysiologicconcentrations.AIDS.2002Apr12;16(6):859-63.PMID:11919487.

CaronM,AuclairM,VigourouxC,etal.TheHIVproteaseinhibitorindinavirimpairssterolregulatoryelement-bindingprotein-1intranuclearlocalization,inhibitspreadipocytedifferentiation,andinducesinsulinresistance.Diabetes.2001Jun;50(6):1378-88.PMID:11375339.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂