Itopride is an inhibitor of acetylcholinesterase (AChE) and D2 receptors; it exhibits prokinetic gastrointestinal motility modulating activity. Itopride is clinically used to treat functional dyspepsia and gastroesophageal reflux disease (GERD). Itopride inhibits lower esophageal sphincter relaxation.
| Cas No. | 122892-31-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H26N2O4 HCl |
| Formula Wt. | 394.88 |
| Chemical Name | N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4- dimethoxy-benzamide |
| IUPAC Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide;hydrochloride |
| Melting Point | 191-195°C |
| Solubility | Soluble in water or methanol. Sparingly soluble in acetic acid. |
| Appearance | White to off-white crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | I7757 Info Sheet PDF |
|---|
Huang X, Lv B, Zhang S, et al. Itopride therapy for functional dyspepsia: a meta-analysis. World J Gastroenterol. 2012 Dec 28;18(48):7371-7. PMID: 23326147.
Scarpellini E, Vos R, Blondeau K, et al. The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man. Aliment Pharmacol Ther. 2011 Jan;33(1):99-105. PMID: 21083582.
Lim HC, Kim YG, Lim JH, et al. Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8. PMID: 18581598.
Fujitsuka N, Asakawa A, Hayashi M, et al. Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biol Psychiatry. 2009 May 1;65(9):748-759. PMID: 19058784.
