Itoprideisaninhibitorofacetylcholinesterase(AChE)andD2receptors;itexhibitsprokineticgastrointestinalmotilitymodulatingactivity.Itoprideisclinicallyusedtotreatfunctionaldyspepsiaandgastroesophagealrefluxdisease(GERD).Itoprideinhibitsloweresophagealsphincterrelaxation.
| CasNo. | 122892-31-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H26N2O4HCl |
| FormulaWt. | 394.88 |
| ChemicalName | N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide |
| IUPACName | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide;hydrochloride |
| MeltingPoint | 191-195°C |
| Solubility | Solubleinwaterormethanol.Sparinglysolubleinaceticacid. |
| Appearance | Whitetooff-whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I7757InfoSheetPDF |
|---|
HuangX,LvB,ZhangS,etal.Itopridetherapyforfunctionaldyspepsia:ameta-analysis.WorldJGastroenterol.2012Dec28;18(48):7371-7.PMID:23326147.
ScarpelliniE,VosR,BlondeauK,etal.Theeffectsofitoprideonoesophagealmotilityandloweroesophagealsphincterfunctioninman.AlimentPharmacolTher.2011Jan;33(1):99-105.PMID:21083582.
LimHC,KimYG,LimJH,etal.Effectofitopridehydrochlorideontheilealandcolonicmotilityinguineapiginvitro.YonseiMedJ.2008Jun30;49(3):472-8.PMID:18581598.
FujitsukaN,AsakawaA,HayashiM,etal.SelectiveSEROtoninreuptakeinhibitorsmodifyphysiologicalgastrointestinalmotoractivitiesvia5-HT2creceptorandacylghrelin.BiolPsychiatry.2009May1;65(9):748-759.PMID:19058784.
