Description
100µgeachof13kavacompounds/mLacetonitrile.KavalactonesarefoundinPipermethysticumandexertawidevarietyofactivitiesinvitroandinvivo,includingantinociceptive,anxiolytic,hypnotic,anticonvulsant,andanti-inflammatoryeffects.Kavalactonesshortensleeplatencyanddecreaseawaketimeinsleep-disturbedratsandeffectivelytreatshort-termanxietyinhumans.Inanimals,thesecompoundsalsoactivateNrf2,atranscriptionfactorprotectiveagainstaβ-inducedneurotoxicityinAlzheimer’sdiseaseandinhibitMPTP-inducedlossofDA,tyrosinehydroxylase,andnigralneuronsinmodelsofParkinson’sdisease.Additionally,kavalactonesmodulateNa+,K+,andCa2+ionchannelsignalingaswellaschemicalandthermalpainnociception.
References
KormannEC,AmaralPdeA,DavidM,etal.Kavainanaloguesaspotentialanalgesicagents.PharmacolRep.2012;64(6):1419-26.PMID:23406752.
TsutsuiR,ShinomiyaK,TakedaY,etal.Hypnoticandsleepquality-enhancingpropertiesofkavaininsleep-disturbedrats.JPharmacolSci.2009Nov;111(3):293-8.PMID:19881224.
WruckCJ,GötzME,HerdegenT,etal.Kavalactonesprotectneuralcellsagainstamyloidbetapeptide-inducedneurotoxicityviaextracellularsignal-regulatedkinase1/2-dependentnuclearfactorerythroid2-relatedfactor2activation.MolPharmacol.2008Jun;73(6):1785-95.PMID:18334601.
PittlerMH,ErnstE.Kavaextractfortreatinganxiety.CochraneDatabaseSystRev.2003;(1):CD003383.PMID:12535473.
GrunzeH,LangoschJ,SchirrmacherK,etal.KavapyronesexerteffectsonneuronaltransmissionandtransmembraneouscationcurrentssimilartoestablishedmoodstABIlizers--areview.ProgNeuropsychopharmacolBiolPsychiatry.2001Nov;25(8):1555-70.PMID:11642654.
SchmidtN,FergerB.Neuroprotectiveeffectsof(+/-)-kavainintheMPTPmousemodelofParkinson"sdisease.Synapse.2001Apr;40(1):47-54.PMID:11170221.
