Lansoprazoleisaprotonpump(H+/K+ATPase)inhibitor(PPI)thatexhibitsantacidandanti-inflammatoryactivities.Lansoprazoleisclinicallyusedtotreatgastroesophagealrefluxdisease(GERD).Lansoprazoleinhibitsindomethacin-inducedgastricdamagebypreventingactivationofmitochondria-andFas-mediatedapoptosissignalingpathways.LansoprazolealsoinhibitsPMA-inducedactivationofERK1/2andLPS-inducedactivationofp38MAPKinneutrophilsanddecreaseslevelsofpro-inflammatorycytokinesinmacrophages.
| CasNo. | 103577-45-3 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14F3N3O2S |
| FormulaWt. | 369.36 |
| ChemicalName | 1H-Benzimidazole,2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)- |
| IUPACName | 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole |
| Synonym | AG-1749;Agopton;Lansox;Lanzor;Limpidex. |
| MeltingPoint | 178-182°C(dec) |
| Solubility | Insolubleinwater.SolubleinmethanolandDMF. |
| Appearance | Awhitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | L0254MSDSPDF |
|---|---|
| InfoSheet | L0254InfoSheetPDF |
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MaityP,BinduS,ChoubeyV,etal.Lansoprazoleprotectsandhealsgastricmucosafromnon-steroidalanti-inflammatorydrug(NSAID)-inducedgastropathybyinhibitingmitochondrialaswellasFas-mediateddeathpathwayswithconcurrentinductionofmucosalcellrenewal.JBiolChem.2008May23;283(21):14391-401.PMID:18375387.
HinokiA,YoshimuraK,FujitaK,etal.Suppressionofproinflammatorycytokineproductioninmacrophagesbylansoprazole.PediatrSurgInt.2006Nov;22(11):915-23.PMID:16932910.
ShinJM,ChoYM,SachsG.Chemistryofcovalentinhibitionofthegastric(H+,K+)-ATPasebyprotonpumpinhibitors.JAmChemSoc.2004Jun30;126(25):7800-11.PMID:15212527.
