Description
Met-enkephalinisanendogenousopioidpeptidethatactsasanagoNISTatμ-opioidreceptors(μORs)andδ-opioidreceptors(δORs).Met-enkephalinexhibitsneuromodulatory,antinociceptive/analgesic,antidepressant,andgastrointestinalmotilitymodulatingactivities.Likeotherendogenousopioids,met-enkephalinmodulatesexpressionofopioidreceptorsandplaysaroleinreward/reinforcementsignaling.Met-enkephalinisalsoinvolvedinexercise-inducedreversalofneuropathicpainandinanimalsundergoingtheforcedswimtest,decreasesimmobilitytime.Met-enkephalininhibitsgastrointestinalmusclecontractility,inhibitingmotilityandgastricemptying.Additionally,analogsofthispeptidedisplayanticancerandantiepileptic/anticonvulsantactivities.
References
Gonzalez-NunezV,JimenezGonzálezA,Barreto-ValerK,etal.Invivoregulationoftheμopioidreceptor:roleoftheendogenousopioidagents.MolMed.2013Mar5;19:7-17.PMID:23348513.
FanningRA,McMorrowJP,CampionDP,etal.Opioidmediatedactivityandexpressionofmuanddeltaopioidreceptorsinisolatedhumantermnon-labouringmyometrium.EurJPharmacol.2013Jan5;698(1-3):170-7.PMID:23051674.
HadjiconstantinouM,NeffNH.Nicotineandendogenousopioids:neuRochemicalandpharmacologicalevidence.Neuropharmacology.2011Jun;60(7-8):1209-20.PMID:21108953.
StaggNJ,MataHP,IbrahimMM,etal.Regularexercisereversessensoryhypersensitivityinaratneuropathicpainmodel:roleofendogenousopioids.Anesthesiology.2011Apr;114(4):940-8.PMID:21386701.
GredicakM,SupekF,KraljM,etal.Computationalstructure-activitystudydirectssynthesisofnovelantitumorenkephalinanalogs.AminoAcids.2010Apr;38(4):1185-91.PMID:19639251.
LeeHK,SmithMD,SmithBJ,etal.AnticonvulsantMet-enkephalinanaloguescontainingbackbonespacersrevealalternativenon-opioidsignalinginthebrain.ACSChemBiol.2009Aug21;4(8):659-71.PMID:19634861.
