LKT/METFORMIN HYDROCHLORIDE/M2076/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/METFORMIN HYDROCHLORIDE/M2076/5 g

LKT/METFORMIN HYDROCHLORIDE/M2076/5 g

商品编号： M2076-5g

品牌： lktlabs

市场价： ¥620.00

美元价： 372.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDM2076

CasNo.1115-70-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

MetforminisanAMPKactivatorthatexhibitsanti-diabetic,antihyperglycemic,antioxidative,immunosuppressive,anticancerchemotherapeutic,anti-metastatic,andchemopreventiveactivities.Metforminmodulatesglucose-6-phosphataseactivity,decreasingglucoseproductionandglycogenolysis.Additionally,itinhibitsexpressionofTNF-αintheliver,reversingpathologyoffattyliverdiseaseinvivo.Inpodocytes,metformindecreasesactivityofNADPHoxidaseandgenerationoffreerADIcals.Inotherinvitromodels,metformininhibitsexpressionofMHCmoleculesandco-stimulatoryfactorsondendriticcells,preventingantigenpresentation.Acrossseveralhepatocellularcarcinomacelllines,metformindecreasesexpressionofcyclinD1,cyclinE,andCDK4,inducingG0/G1phasecellcyclearrestandinhibitingcellproliferation.Invivo,thiscompoundalsodownregulatesexpressionofc-myc,preventingneoplasiainitiationinprostatecancermodels.Metformin’sactivationofAMPKalsoinhibitsShhsignalinginbreastcancermodels,suppressingproliferation,migration,andinvasion.

ProductInfo

CasNo.	1115-70-4
Purity	≥98%
Formula	C₄H₁₁N₅•HCl
FormulaWt.	165.62
ChemicalName	1,1-DimethylbiguanideHydrochloride
IUPACName	3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
Synonym	Dimethylbiguanidehydrochloride;Imidodicaronimidicdiamide;N,N-dimethyl-,monohydrochloride;N,N-Dimethylbiguanidehydrochloride
MeltingPoint	223-226
Solubility	100mMwater,50mMDMSO
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	M2076MSDSPDF
InfoSheet	M2076InfoSheetPDF
Brochures	MetforminFlyer

References

FanC,WangY,LiuZ,etal.MetforminexertsanticancereffectsthroughtheinhibitionoftheSonichedgehogsignalingpathwayinbreastcancer.IntJMolMed.2015May21.[Epubaheadofprint].PMID:25999130.

MiyoshiH,KatoK,IwamaH,etal.Effectoftheanti-diabeticdrugmetformininhepatocellularcarcinomainvitroandinvivo.IntJOncol.2013Dec30.[Epubaheadofprint].PMID:24378856.

PiwkowskaA,RogackaD,JankowskiM,etal.MetforminreducesNAD(P)HoxidaseactivityinmouseculturedpodocytesthroughpurinergicdependentmechanismbyincreasingextracellularATPconcentration.ActaBiochimPol.2013;60(4):607-12.PMID:24432311.

AkinyekeT,MatsumuraS,WangX,etal.Metformintargetsc-MYConcogenetopreventprostatecancer.Carcinogenesis.2013Dec;34(12):2823-32.PMID:24130167.

ZhangY,GuanM,ZhengZ,etal.EffectsofmetforminonCD133+colorectalcancercellsindiabeticpatients.PLoSOne.2013Nov21;8(11):e81264.PMID:24278407.

ShinS,HyunB,LeeA,etal.MetforminSuppressesMHC-RestrictedAntigenPresentationbyInhibitingCo-StimulatoryFactorsandMHCMoleculesinAPCs.BiomolTher(Seoul).2013Jan;21(1):35-41.PMID:24009856.

ChuCA,WiernspergerN,MuscatoN,etal.Theacuteeffectofmetforminonglucoseproductionintheconsciousdogisprimarilyattributabletoinhibitionofglycogenolysis.Metabolism.2000Dec;49(12):1619-26.PMID:11145127.

LinHZ,YangSQ,ChuckareeC,etal.Metforminreversesfattyliverdiseaseinobese,leptin-deficientmice.NatMed.2000Sep;6(9):998-1003.PMID:10973319.

MinassianC,TarpinS,MithieuxG.Roleofglucose-6phosphatase,glucokinase,andglucose-6phosphateinliverinsulinresistanceanditscorrectionbymetformin.BiochemPharmacol.1998Apr15;55(8):1213-9.PMID:9719475.

StumvollM,NurjhanN,PerrielloG,etal.Metaboliceffectsofmetformininnon-insulin-dependentdiabetesmellitus.NEnglJMed.1995Aug31;333(9):550-4.PMID:7623903.

NakamichiN,ShimaH,AsanoS,etal.Involvementofcarnitine/organiccationtransporterOCTN1/SLC22A4ingastrointestinalabsorptionofmetformin.JPharmSci.2013Sep;102(9):3407-3417.PMID:23666872.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂