Mitiglinideisananti-diabetic/anti-hyperglycemiccompoundthatincreasesinsulinsecretionanddecreasesplasmaglucoseinpancreaticβcells.Theshortactionofmitiglinidemimicstheinvivodurationandtimingofinsulinrelease.MitiglinidedecreaseslevelsofFGF-21,alteringglucosemetabolism.MitiglinidedirectlyinhibitsATP-sensitiveK+channelsandmayalsoactivateryanodine(RyR)receptors,alteringintracellularCa2+release.
| CasNo. | 145375-43-5 |
|---|---|
| Purity | ≥98% |
| Formula | 2(C19H24NO3)Ca |
| FormulaWt. | 668.88 |
| IUPACName | 4-(1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-2-benzyl-4-oxobutanoicacidInChI:InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M3577InfoSheetPDF |
|---|
PhillippeHM,WargoKA.Mitiglinidefortype2diabetestreatment.ExpertOpinPharmacother.2013Oct;14(15):2133-44.PMID:23992284.
WangB,YangG,YangM,etal.Mitiglinidetreatmentmaydecreasesplasmafibroblastgrowthfactor-21levelsinindividualswithnew-onsetT2DM.Cytokine.2012Feb;57(2):300-3.PMID:22129626.
PhillippeHM,WargoKA.Mitiglinide:anovelagentforthetreatmentoftype2diabetesmellitus.AnnPharmacother.2010Oct;44(10):1615-23.PMID:20841518.
ShigetoM,KatsuraM,MatsudaM,etal.Nateglinideandmitiglinide,butnotsulfonylureas,induceinsulinsecretionthroughamechanismmediatedbycalciumreleasefromendoplasmicreticulum.JPharmacolExpTher.2007Jul;322(1):1-7.PMID:17409272.
