Myomodulinisaneuromodulatorypeptidefoundinmolluscs,insects,andgastropods.Inleeches,myomodulininhibitsactivityoftheNa+/K+pump,increasinghyperpolarization-activatedcurrentI(h)andalteringheartneuronspikeandburstfrequency.Inglialcellmembranes,myomodulinevokesmembraneoutwardcurrentsandelicitsincreasesinK+conductance.Acrossmanycellularmodels,myomodulinmodulatesK+,Na+,andCa2+currentamplitudes.Additionally,myomodulinincreasesmusclecontractionfrequency,increasinggutmotility.
| CasNo. | 110570-93-9 |
|---|---|
| Purity | ≥95% |
| Formula | C36H67N11O8S2 |
| FormulaWt. | 846.13 |
| IUPACName | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide |
| Synonym | MyomodulinA,MyomodulineA |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M9356InfoSheetPDF |
|---|
TobinAE,CalabreseRL.MyomodulinincreasesIhandinhibitstheNA/Kpumptomodulateburstinginleechheartinterneurons.JNeurophysiol.2005Dec;94(6):3938-50.PMID:16093342.
BritzFC,DeitmerJW.Membraneresponsesoftheleechgiantglialcelltothepeptidetransmittermyomodulin.Peptides.2002Dec;23(12):2117-25.PMID:12535690.
WangY,StrongJA,SahleyCL.ModulatoryeffectsofmyomodulinontheexcitABIlityandmembranecurrentsinRetziuscellsoftheleech.JNeurophysiol.1999Jul;82(1):216-25.PMID:10400950.
PerrySJ,StraubVA,KemenesG,etal.NeuralmodulationofgutmotilitybymyomodulinpeptidesandacetylcholineinthesnailLymnaea.JNeurophysiol.1998May;79(5):2460-74.PMID:9582220.
