LKT/柚皮素/N0068/5克-免疫在线蚂蚁淘旗下平台

商品详细LKT/柚皮素/N0068/5克

LKT/柚皮素/N0068/5克

商品编号： N0068-5g

品牌： lktlabs

市场价： ¥1540.00

美元价： 924.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN0068

CasNo.67604-48-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Naringeninisaphytoestrogenandflavanonefoundincitrusfruits.Naringeninexhibitsantioxidative,anti-inflammatory,hepatoprotective,neuroprotective,immunomodulatory,anti-metastatic,anti-asthma,anti-allergic,anti-fibrotic,anti-metastatic,antiviral,antidepressant,anticancer,andgastrointestinalmotilitymodulatingactivities.NaringenininhibitsoxidativedamageinanimalmodelsofAlzheimer’sdiseaseandprotectsagainst6-OHDA-inducedneurodegenerationbyincreasinglevelsofNrf2inanimalmodelsofParkinson’sdisease.InanimalmodelsofCCl4-inducedliverinjury,naringenininhibitslipidperoxidation,increaseslevelsofglutathione,HO-1,andNrf2,anddecreaseslevelsofTNF-α,COX-2,andiNOS.Inmacrophages,naringeninaltersexpressionoftoll-likereceptors2and4(TLR2,TLR4)andCD86;italsoinhibitsTreg-inducedsuppressionandlimitsmetastasisinanimalmodels.Inotheranimalmodels,naringenininhibitsallergen-inducedairwayinflammation.Naringeninalsodecreaseslevelsofα-SMA,collagentypeI,fibronectin,andERK1/2infibroblasts.Inleukemiacells,naringenininducesapoptosis,decreasesthemitochondrialmembranepotentialandlevelsofBcl-2,andincreaseslevelsofBax.ThiscompoundalsoshowsbenefitinthetailsUSPensiontestandinhibitshepatitisCviralassembly.

ProductInfo

CasNo.	67604-48-2
Purity	≥98%
Formula	C₁₅H₁₂O₅
FormulaWt.	272.25
ChemicalName	2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)4H-1-benzopyran-4-one
IUPACName	(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Synonym	4",5,7-Trihydroxyflavanone;naringetol;salipurpol;pelargidanon1602
MeltingPoint	247-250°C
Solubility	Insolubleinwater.Solubleinethanol(50mg/ml),DMSO,methanol.
Appearance	Whitetoyellowpowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	N0068MSDSPDF
InfoSheet	N0068InfoSheetPDF

References

EsmaeiliMA,AlilouM.NaringeninattenuatesCCl4-inducedhepaticinflammationbytheactivationofanNrf2-mediatedpathwayinrats.ClinExpPharmacolPhysiol.2014Jun;41(6):416-22.PMID:24684352.

ChtourouY,FetouiH,GdouraR.Protectiveeffectsofnaringeninoniron-overload-inducedcerebralcortexneurotoxicitycorrelatedwithoxidativestress.BiolTraceElemRes.2014Jun;158(3):376-83.PMID:24682942.

LouH,JingX,WeiX,etal.Naringeninprotectsagainst6-OHDA-inducedneurotoxicityviaactivationoftheNrf2/AREsignalingpathway.Neuropharmacology.2014Apr;79:380-8.PMID:24333330.

KimS,ParkTI.Naringenin:apartialagoNISTonestrogenreceptorinT47D-KBlucbreastcancercells.IntJClinExpMed.2013Oct25;6(10):890-9.PMID:24260594.

YilmaAN,SinghSR,MoriciL,etal.Flavonoidnaringenin:apotentialimmunomodulatorforChlamydiatrachomatisinflammation.MediatorsInflamm.2013;2013:102457.PMID:23766556.

JangY,KimSW,OhJ,etal.Ghrelinreceptorisactivatedbynaringinandnaringenin,constituentsofaprokineticagentPoncirusfructus.JEthnopharmacol.2013Jul9;148(2):459-65.PMID:23639361.

JungJW,ParkIH,ChoJS,etal.Naringenininhibitsextracellularmatrixproductionviaextracellularsignal-regulatedkinasepathwaysinnasalpolyp-derivedfibroblasts.PhytotherRes.2013Mar;27(3):463-7.PMID:22674629.

GoldwasserJ,CohenPY,LinW,etal.Naringenininhibitstheassemblyandlong-termproductionofinfectioushepatitisCvirusparticlesthroughaPPAR-mediatedmechanism.JHepatol.2011Nov;55(5):963-71.PMID:21354229.

QinL,JinL,LuL,etal.Naringeninreduceslungmetastasisinabreastcancerresectionmodel.ProteinCell.2011Jun;2(6):507-16.PMID:21748601.

YiLT,LiCF,ZhanX,etal.Involvementofmonoaminergicsystemintheantidepressant-likeeffectoftheflavonoidnaringenininmice.ProgNeuropsychopharmacolBiolPsychiatry.2010Oct1;34(7):1223-8.PMID:20603175.

ShiY,DaiJ,LiuH,etal.Naringenininhibitsallergen-inducedairwayinflammationandairwayresponsivenessandinhibitsNF-kappaBactivityinamurinemodelofasthma.CanJPhysiolPharmacol.2009Sep;87(9):729-35PMID:19794524.

ParkJH,JinCY,LeeBK,etal.NaringenininducesapoptosisthroughdownregulationofAktandcaspase-3activationinhumanleukemiaTHP-1cells.FoodChemToxicol.2008Dec;46(12):3684-90.PMID:18930780.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂