Naproxenisapropionicnon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsantipyretic,analgesic,anti-inflammatory,andantiviralactivities.NaproxeninhibitsCOX-1andCOX-2andisclinicallyusedtotreatfever,swelling,andpain.Invitro,naproxeninhibitsinfluenzavirusinfectionthroughbindingofthenucleoproteinandpreventinginitiationoftranscriptionandreplication.
| CasNo. | 22204-53-1 |
|---|---|
| Purity | ≥98% |
| Formula | C14H14O3 |
| FormulaWt. | 230.26 |
| ChemicalName | S(+)6-Methoxy-αmethyl-2-naphthaleneaceticacid |
| IUPACName | (2S)-2-(6-methoxynaphthalen-2-yl)propanoicacid |
| Synonym | S-Naproxen,Nonyl;Equiproxen;Napren;Pranoxen |
| MeltingPoint | 155-158°C |
| Solubility | Solubleinethanolandacetone.Insolubleinwater. |
| Appearance | WhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | N0061MSDSPDF |
|---|---|
| InfoSheet | N0061InfoSheetPDF |
LejalN,TarusB,BouguyonE,etal.Structure-baseddiscoveryofthenovelantiviralpropertiesofnaproxenagainstthenucleoproteinofinfluenzaAvirus.AntimicrobAgentsChemother.2013May;57(5):2231-42.PMID:23459490.
DugganKC,WaltersMJ,MuseeJ,etal.Molecularbasisforcyclooxygenaseinhibitionbythenon-steroidalanti-inflammatorydrugnaproxen.JBiolChem.2010Nov5;285(45):34950-9.PMID:20810665.
