D,L-Tetrahydropalmatine is an alkaloid found in Corydalis and Stephania that exhibits analgesic, antinociceptive, anxiolytic, antidepressant, and anti-parasitic activities. This compound inhibits D1/2 receptors and may also inhibit L-type Ca2+ channels and some K+ channels. D,L-Tetrahydropalmatine decreases anxiety measures in the elevated plus maze and alters thresholds in assays of thermal, mechanical, and chemical pain. D,L-Tetrahydropalmatine also inhibits growth of Plasmodium.
| Cas No. | 10097-84-4 |
|---|---|
| Purity | ≥98% |
| Formula | C21H25NO4 |
| Formula Wt. | 355.43 |
| Chemical Name | 5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H- dibenzo[a,g]quinolizine |
| IUPAC Name | (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| Synonym | Tetrahydropalmatine; Hynndarin |
| Melting Point | 148-149°C |
| Appearance | White crystalline |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T1678 Info Sheet PDF |
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Baghdikian B, Mahiou-Leddet V, Bory S, et al. New antiplasmodial alkaloids from Stephania rotunda. J Ethnopharmacol. 2013 Jan 9;145(1):381-5. PMID: 23127648.
Cao FL, Shang GW, Wang Y, et al. Antinociceptive effects of intragastric DL-tetrahydropalmatine on visceral and somatic persistent nociception and pain hypersensitivity in rats. Pharmacol Biochem Behav. 2011 Nov;100(1):199-204. PMID: 21889526.
Henkes H, Franz M, Kendall O, et al. Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. AANA J. 2011 Aug;79(4 Suppl):S75-80. PMID: 22403971.
