Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine. Danofloxacin exhibits broad spectrum antibacterial activity against species of Mycoplasma, Actinobacillus, Mannheima, Escherichia, and Pasturella. In renal epithelial cells, danofloxacin also increases activity of antioxidative enzymes, including superoxide dismutase (SOD) and catalase.
| Cas No. | 119487-55-6 |
|---|---|
| Purity | ≥98% |
| Formula | C19H20FN3O3 • CH3SO3H |
| Formula Wt. | 453.48 |
| IUPAC Name | 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-oxoquinoline-3-carboxylic acid |
| Melting Point | 263 |
| Solubility | Soluble in water |
| Appearance | White or Off-white cyrstalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | D0353 MSDS PDF |
|---|---|
| Info Sheet | D0353 Info Sheet PDF |
Kawai K, Higuchi H, Iwano H, et al. Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Anim Sci J. 2013 Nov 21. [Epub ahead of print]. PMID: 24261609.
Yu CH, Liu ZY, Sun LS, et al. Effect of Danofloxacin on Reactive Oxygen Species Production, Lipid Peroxidation and Antioxidant Enzyme Activities in Kidney Tubular Epithelial Cell Line, LLC-PK1. Basic Clin Pharmacol Toxicol. 2013 Jul 15. [Epub ahead of print]. PMID: 23855763.
Archambault M, Harel J, Gouré J, et al. Antimicrobial susceptibilities and resistance genes of Canadian isolates of Actinobacillus pleuropneumoniae. Microb Drug Resist. 2012 Apr;18(2):198-206. PMID: 22204596.
TerHune TN, Skogerboe TL, Shostrom VK, et al. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. Am J Vet Res. 2005 Feb;66(2):342-9. PMID: 15757137.
Raemdonck DL, Tanner AC, Tolling ST, et al. In vitro susceptibility of avian Escherichia coli and Pasteurella multocida to danofloxacin and five other antimicrobials. Avian Dis. 1992 Oct-Dec;36(4):964-7. PMID: 1336664.
