Dapivirineisanon-nucleosidereversetranscriptaseinhibitor(NNRTI)thatiscurrentlyinclinicaltrialsasaprophylacticagainstHIVinfection.InvariousmodelssuchasdendriticcellsandTcells,dapivirineexhibitsantiviralactivitybysuppressingviralreplication.
| CasNo. | 244767-67-7 |
|---|---|
| Purity | ≥98% |
| Formula | C20H19N5 |
| FormulaWt. | 329.41 |
| IUPACName | 4-{[4-(Mesitylamino)-2-pyrimidinyl]amino}benzonitrile |
| Synonym | TMC120 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D0261InfoSheetPDF |
|---|---|
| Brochures | AntiviralsBooklet |
DevlinB,NuttallJ,WilderS,etal.DevelopmentofdapivirinevaginalringforHIVprevention.AntiviralRes.2013Dec;100Suppl:S3-8.PMID:24188702.
GuptaSK,Nutan.ClinicaluseofvaginalorrectallyappliedmicrobicidesinpatientssufferingfromHIV/AIDS.HIVAIDS(Auckl).2013Oct22;5:295-307.PMID:24174883.
NjaiHF,LewiPJ,JanssenCG,etal.Pre-incubationofcell-freeHIV-1groupMisolateswithnon-nucleosidereversetranscriptaseinhibitorsblockssubsequentviralreplicationinco-culturesofdendriticcellsandTcells.AntivirTher.2005;10(2):255-62.PMID:15865220.
VanHerrewegeY,MichielsJ,VanRoeyJ,etal.InvitroevaluationofnonnucleosidereversetranscriptaseinhibitorsUC-781andTMC120-R147681ashumanimmunodeficiencyvirusmicrobicides.AntimicrobAgentsChemother.2004Jan;48(1):337-9.PMID:14693562.
