LKT/DEMETHOXYCURCUMIN/D1850/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/DEMETHOXYCURCUMIN/D1850/5 mg

LKT/DEMETHOXYCURCUMIN/D1850/5 mg

商品编号： D1850-5mg

品牌： lktlabs

市场价： ¥2680.00

美元价： 1608.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDD1850

CasNo.24939-17-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Demethoxycurcumindisplaysanticancer,antioxidative,anti-inflammatory,antibacterial,andneuroprotectiveactivities.DemethoxycurcuminactivatesAMPK,inhibitingeukaryoticinitiationfactor4Ebindingprotein1(eIF4E-bp3)anddownregulatingHSP70andEGFRinvitro.Likeothersimilarcompounds,demethoxycurcuminmayindirectlyinhibitEGFRactivation.DemethoxycurcuminalsoinhibitsSTAT3activationandincreasesactivityofcaspase3invitro,inhibitingcellproliferation,migration,andinvasioninseveralcancercelllines.Demethoxycurcumindownregulatesreactiveoxygenspecies(ROS)-relatedsignalinginvitroaswell.Thiscompoundinhibitsphosphorylationoftauproteinsandmayinhibitacetylcholinesterase(AChE)activityinvitro,suggestingpotentialbenefitinthetreatmentofAlzheimer’sdisease.Demethoxycurcuminmayalsobeapotentialtreatmentforvascularinjury,asitdecreasesexpressionofmatrixmetalloproteinase2/9anddownregulatesPI3K/AktandERK1/2signaling,preventingmigrationofvascularsmoothmusclecellsinvitro.ThiscompoundalsodisplaysantibacterialactivityagainstMycobacteriumtuberculosis.

ProductInfo

CasNo.	24939-17-1
Purity	≥98%
Formula	C₂₀H₁₈O₅
FormulaWt.	338.35
ChemicalName	1,6-HeptADIene-3,5-dione,1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-(VAN)
IUPACName	(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
Appearance	OrangePowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	D1850MSDSPDF
InfoSheet	D1850InfoSheetPDF
Brochures	CurcuminFlyer
	NaturalProductsBooklet

References

SheuMJ,LinHY,YangYH,etal.Demethoxycurcumin,amajoractivecurcuminoidfromCurcumalonga,suppressesballooninjuryinducedvascularsmoothmusclecellmigrationandneointimaformation:aninvitroandinvivostudy.MolNutrFoodRes.2013Sep;57(9):1586-97.PMID:23520190.

ShiehJM,ChenYC,LinYC,etal.DemethoxycurcumininhibitsenergymetabolicandoncogenicsignalingpathwaysthroughAMPKactivationintriple-negativebreastcancercells.JAgricFoodChem.2013Jul3;61(26):6366-75.PMID:23777448.

VillafloresOB,ChenYJ,ChenCP,etal.Curcuminoidsandresveratrolasanti-Alzheimeragents.TaiwanJObstetGynecol.2012Dec;51(4):515-25.PMID:23276553.

HungCM,SuYH,LinHY,etal.DemethoxycurcuminModulatesProstateCancerCellProliferationviaAMPK-InducedDown-regulationofHSP70andEGFR.JAgricFoodChem.2012Aug16.PMID:22849866.

NiX,ZhangA,ZhaoZ,etal.Demethoxycurcumininhibitscellproliferation,migrationandinvasioninprostatecancercells.OncolRep.2012Jul;28(1):85-90.PMID:22552297.

ZhangL,WuC,ZhaoS,etal.Demethoxycurcumin,anaturalderivativeofcurcuminattenuatesLPS-inducedpro-inflammatoryresponsesthroughdown-regulationofintracellularROS-relatedMAPK/NF-kappaBsignalingpathwaysinN9microgliainducedbylipopolysaccharide.IntImmunopharmacol.2010Mar;10(3):331-8.PMID:20018257.

AhmedT,GilaniAH.Inhibitoryeffectofcurcuminoidsonacetylcholinesteraseactivityandattenuationofscopolamine-inducedamnesiamayexplainmedicinaluseofturmericinAlzheimer"sdisease.PharmacolBiochemBehav.2009Feb;91(4):554-9.PMID:18930076.

AgrawalDK,SaikiaD,TiwariR,etal.Demethoxycurcuminanditssemisyntheticanaloguesasantitubercularagents.PlantaMed.2008Dec;74(15):1828-31.PMID:18991209.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂