Dermaseptinisacationicantimicrobialpeptide(AMP)thatexhibitsantibacterialactivityagainstAcinetobacterandPseudomonas.DermaseptinincreasespermeABIlityofcellmembranes.Dermaseptinalsoexhibitsanticancerchemotherapeuticandanti-angiogenicactivities,inhibitingproliferation,colonyformation,andcapillaryformationinvitroaswellastumorgrowthinanimalmodelsofprostateadenocarcinoma.
| Purity | ≥96% |
|---|---|
| Formula | C152H257N43O44S2 |
| FormulaWt. | 3455.08 |
| ChemicalName | Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln |
| Appearance | Whitetooff-whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D1768InfoSheetPDF |
|---|
JiangZ,VasilAI,VasilML,etal."SpecificityDeterminants"ImproveTherapeuticIndicesofTwoAntimicrobialPeptidesPiscidin1andDermaseptinS4AgainsttheGram-negativePathogensAcinetobacterbaumanniiandPseudomonasaeruginosa.Pharmaceuticals(Basel).2014Mar25;7(4):366-91.PMID:24670666.
CaillonL,KillianJA,LequinO,etal.Biophysicalinvestigationofthemembrane-disruptingmechanismoftheantimicrobialandamyloid-likepeptidedermaseptinS9.PLoSOne.2013Oct11;8(10):e75528.PMID:24146759.
vanZoggelH,CarpentierG,DosSantosC,etal.AntitumorandangiostaticactivitiesoftheantimicrobialpeptidedermaseptinB2.PLoSOne.2012;7(9):e44351.PMID:23028527.
