Description
Diallyltetrasulfideisanorganosulfurthatdisplaysanticancer,antioxidative,andantimicrobialproperties.Invitro,diallyltetrasulfideincreasesreactiveoxygenspecies(ROS)andhemeoxygenase-1levelsandinhibitsmicrotubulepolymerization,inducingmitoticarrest.Diallyltetrasulfideexhibitsantibacterialandantifungalbenefitagainstmanymicrobes,includingincludingStaphylococcusaureus,methicillin-resistantStaphylococcusaureus(MRSA),andseveralspeciesofCandidaandAspergillus.Additionally,thiscompounddecreasescadmium-mediatedoxidativedamageinseveralanimalmodels,increasinglevelsofsuperoxidedismutase,glutathioneperoxidase,andotherglutathionemetabolizingenzymes.
References
SaiduNE,AbuAsaliI,CzepukojcB,etal.Comparisonbetweentheeffectsofdiallyltetrasulfideonhumanretinapigmentepithelialcells(ARPE-19)andHCT116cells.BiochimBiophysActa.2013Nov;1830(11):5267-76.PMID:23948592.
KelkelM,CerellaC,MackF,etal.ROS-independentJNKactivationandmultisitephosphorylationofBcl-2linkdiallyltetrasulfide-inducedmitoticarresttoapoptosis.Carcinogenesis.2012Nov;33(11):2162-71.PMID:22822094.
PonnusamyM,PariL.Protectiveroleofdiallyltetrasulfideoncadmium-inducedtesticulardamageinadultrats:abiochemicalandhistologicalstudy.ToxicolIndHealth.2011Jun;27(5):407-16.PMID:21245201.
TsaoSM,YinMC.In-vitroantimicrobialactivityoffourdiallylsulphidesoccurringnaturallyingarlicandChineseleekoils.JMedMicrobiol.2001Jul;50(7):646-9.PMID:11444776.
