Description
Diallyl tetrasulfide is an organosulfur that displays anticancer, antioxidative, and antimicrobial properties. In vitro, diallyl tetrasulfide increases reactive oxygen species (ROS) and heme oxygenase-1 levels and inhibits microtubule polymerization, inducing mitotic arrest. Diallyl tetrasulfide exhibits antibacterial and antifungal benefit against many microbes, including including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and several species of Candida and Aspergillus. Additionally, this compound decreases cadmium-mediated oxidative damage in several animal models, increasing levels of superoxide dismutase, glutathione peroxidase, and other glutathione metabolizing enzymes.
References
Saidu NE, Abu Asali I, Czepukojc B, et al. Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells. Biochim Biophys Acta. 2013 Nov;1830(11):5267-76. PMID: 23948592.
Kelkel M, Cerella C, Mack F, et al. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis. 2012 Nov;33(11):2162-71. PMID: 22822094.
Ponnusamy M, Pari L. Protective role of diallyl tetrasulfide on cadmium-induced testicular damage in adult rats: a biochemical and histological study. Toxicol Ind Health. 2011 Jun;27(5):407-16. PMID: 21245201.
Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol. 2001 Jul;50(7):646-9. PMID: 11444776.
