Diaveridineisacoccidiostatusedinveterinarymedicinethatexhibitsanti-parasiticactivity.Diaveridineinhibitsdihydrofolatereductase,preventingfolicacidsynthesisinspeciesofPneumocystis.Diaveridineisalsogenotoxic,inducingstructuralchromosomalaberrationsandinducingDNAdamageinvitro.
| CasNo. | 5355-16-8 |
|---|---|
| Purity | ≥98% |
| Formula | C13H16N4O2 |
| FormulaWt. | 260.29 |
| ChemicalName | 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine-diamine |
| IUPACName | 5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| Synonym | Diaveridin |
| MeltingPoint | 233°C |
| Solubility | SolubleinHClorchloroform(1:600). |
| Appearance | WhiteorAlmost-WhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | D3301MSDSPDF |
|---|---|
| InfoSheet | D3301InfoSheetPDF |
OnoT,SekiyaT,TakahashiY,etal.Thegenotoxicityofdiaveridineandtrimethoprim.EnvironToxicolPharmacol.1997Sep;3(4):297-306.PMID:21781790.
CirioniO,GiacomettiA,ScaliseG.In-vitroactivityofatovaquone,sulphamethoxazoleanddapsonealoneandcombinedwithinhibitorsofdihydrofolatereductaseandmacrolidesagainstPneumocystiscarinii.JAntimicrobChemother.1997Jan;39(1):45-51.PMID:9044027.
WalzerPD,KimCK,FoyJM,etal.InhibitorsoffolicacidsynthesisinthetreatmentofexperimentalPneumocystiscariniipneumonia.AntimicrobAgentsChemother.1988Jan;32(1):96-103.PMID:3258144.
