Diflunisal is a long-acting non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat arthritis and dental pain. Diflunisal inhibits COX-1 and COX-2, exhibiting anti-inflammatory, antipyretic, analgesic, and antiviral activities. In vitro, diflunisal inhibits docking of HIV-1 to LEDGF/p75, preventing viral integration.
| Cas No. | 22494-42-4 |
|---|---|
| Purity | ≥98% |
| Formula | C13H8F2O3 |
| Formula Wt. | 250.20 |
| Chemical Name | 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid |
| IUPAC Name | 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid |
| Synonym | Adomal; Difludol; Dolisal; Dolobid; Dolobis; Flovacil; Fluniget; Fluodonil |
| Melting Point | 210-211°C |
| Solubility | Sparingly soluble in water. |
| Appearance | White Crystalline Powder or Colorless Crystals |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | D3322 MSDS PDF |
|---|---|
| Info Sheet | D3322 Info Sheet PDF |
Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.
Lawton GM, Chapman PJ. Diflunisal--a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain. Aust Dent J. 1993 Aug;38(4):265-71. PMID: 8216032.
