Diflunisalisalong-actingnon-steroidalanti-inflammatorydrug(NSAID)thatisclinicallyusedtotreatarthritisanddentalpain.DiflunisalinhibitsCOX-1andCOX-2,exhibitinganti-inflammatory,antipyretic,analgesic,andantiviralactivities.Invitro,diflunisalinhibitsdockingofHIV-1toLEDGF/p75,preventingviralintegration.
| CasNo. | 22494-42-4 |
|---|---|
| Purity | ≥98% |
| Formula | C13H8F2O3 |
| FormulaWt. | 250.20 |
| ChemicalName | 2",4"-Difluoro-4-hydroxy-[1,1"-biphenyl]-3-carboxylicacid |
| IUPACName | 5-(2,4-difluorophenyl)-2-hydroxybenzoicacid |
| Synonym | Adomal;Difludol;Dolisal;Dolobid;Dolobis;Flovacil;Fluniget;Fluodonil |
| MeltingPoint | 210-211°C |
| Solubility | Sparinglysolubleinwater. |
| Appearance | WhiteCrystallinePowderorColorlessCrystals |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | D3322MSDSPDF |
|---|---|
| InfoSheet | D3322InfoSheetPDF |
HuG,LiX,SunX,etal.IdentificationofolddrugsaspotentialinhibitorsofHIV-1integrase-humanLEDGF/p75interactionviamoleculardocking.JMolModel.2012Dec;18(12):4995-5003.PMID:22733274.
LawtonGM,ChapmanPJ.Diflunisal--along-actingnon-steroidalanti-inflammatorydrug.Areviewofitspharmacologyandeffectivenessinmanagementofpostoperativedentalpain.AustDentJ.1993Aug;38(4):265-71.PMID:8216032.
