LKT/DIMETHOXYCURCUMIN/D3449/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/DIMETHOXYCURCUMIN/D3449/10 mg

LKT/DIMETHOXYCURCUMIN/D3449/10 mg

商品编号： D3449-10mg

品牌： lktlabs

市场价： ¥4480.00

美元价： 2688.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDD3449

CasNo.160096-59-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Likeitsparentcompound,curcumin,thiscurcuminoidexhibitsanticancer,antioxidative,anti-inflammatory,andantibacterialactivities.Inbreastcancercells,dimethoxycurcuminaltersmitochondrialmembranepotential,decreasesATPsynthaseactivity,andinducesDNAdamageandapoptosis.Incomparisontocurcumin,dimethoxycurcuminismorestableanddisplaysgreaterapoptosis-inducingactivityinvitro.Additionally,dimethoxycurcuminismoreeffectiveininhibitionofNOproduction,iNOSexpression,andNF-κBactivationthancurcumin.Dimethoxycurcuminexhibitspro-oxidativeactivityincancercells,increasingreactiveoxygenspecies(ROS),butdoesnotdosoinnormalculturedcells.Thiscompoundalsoinhibitstheexpressionofpro-inflammatorycytokinessuchasIL-2,IL-6,andIFN-γinvitro.Dimethoxycurcuminhasphototoxicantibacterialactivityagainstbothgram-positiveandgram-negativebacteriaandbindstheminorgrooveofDNAwithoutintercalation.

ProductInfo

CasNo.	160096-59-3
Purity	≥98%
Formula	C₂₃H₂₄O₆
FormulaWt.	396.43
IUPACName	(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptADIene-3,5-dione
Appearance	Orangepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	D3449InfoSheetPDF
Brochures	CurcuminFlyer
	NaturalProductsBooklet

References

KunwarA,JayakumarS,SrivastavaAK,etal.Dimethoxycurcumin-inducedcelldeathinhumanbreastcarcinomaMCF7cells:evidenceforpro-oxidantactivity,mitochondrialdysfunction,andapoptosis.ArchToxicol.2012Apr;86(4):603-14.PMID:22119759.

PatwardhanRS,CheckerR,SharmaD,etal.Dimethoxycurcumin,ametabolicallystableanalogueofcurcumin,exhibitsanti-inflammatoryactivitiesinmurineandhumanlymphocytes.BiochemPharmacol.2011Sep15;82(6):642-57.PMID:21726543.

KunwarA,BarikA,SandurSK,etal.Differentialantioxidant/pro-oxidantactivityofdimethoxycurcumin,asyntheticanalogueofcurcumin.FreeRadicRes.2011Aug;45(8):959-65.PMID:21615275.

KunwarA,SimonE,SinghU,etal.InteractionofacurcuminanaloguedimethoxycurcuminwithDNA.ChemBiolDrugDes.2011Apr;77(4):281-7.PMID:21244640

HaukvikT,BruzellE,KristensenS,etal.Ascreeningofcurcuminderivativesforantibacterialphototoxiceffectsstudiesoncurcuminandcurcuminoids.XLIII.Pharmazie.2011Jan;66(1):69-74.PMID:21391438.

PaeHO,JeongSO,KimHS,etal.Dimethoxycurcumin,asyntheticcurcuminanaloguewithhighermetabolicstABIlity,inhibitsNOproduction,inducIBLeNOsynthaseexpressionandNF-kappaBactivationinRAW264.7macrophagesactivatedwithLPS.MolNutrFoodRes.2008Sep;52(9):1082-91.PMID:18481332.

TamvakopoulosC,DimasK,SofianosZD,etal.Metabolismandanticanceractivityofthecurcuminanalogue,dimethoxycurcumin.ClinCancerRes.2007Feb15;13(4):1269-77.PMID:17317839.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂