Doxorubicin is an anthracycline that exhibits anticancer chemotherapeutic and anti-parasitic, antimalarial activities. Doxorubicin is a DNA intercalator that inhibits topoisomerase II and is clinically used to treat various cancers; it is part of the CHOP and ABVD chemotherapy regimens. Doxorubicin also promotes histone H2AX eviction from chromatin, limiting DNA repair mechanisms. Additionally, this compound inhibits growth of Plasmodium.
| Cas No. | 25316-40-9 |
|---|---|
| Purity | ≥98% |
| Formula | C27H29NO11 • HCl |
| Formula Wt. | 579.99 |
| Chemical Name | (8S-cis)10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo- hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroacetyl)-1-methoxy-5,12- naphthacenedione |
| IUPAC Name | (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | Adriacin; Adriblastina; Adriamycin; Caelyx |
| Melting Point | 204-205°C(dec.) |
| Solubility | Soluble in water, methanol or aq alcohols. Soluble in DMSO to 10 mg/mL. Insoluble in acetone, or chloroform. |
| Appearance | Orange-Red Crystal Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | D5794 MSDS PDF |
|---|---|
| Info Sheet | D5794 Info Sheet PDF |
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Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013 Feb;65(2):157-70. PMID: 23278683.
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