LKT/DOXYCYCLINE MONOHYDRATE/D5898/10 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/DOXYCYCLINE MONOHYDRATE/D5898/10 g

LKT/DOXYCYCLINE MONOHYDRATE/D5898/10 g

商品编号： D5898-10g

品牌： lktlabs

市场价： ¥2860.00

美元价： 1716.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDD5898

CasNo.17086-28-1

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Doxycyclineisatetracyclineantibioticthatexhibitsanti-parasitic,anti-helminthic,anti-inflammatory,anticancer,andanti-metastaticactivities.Doxycyclineexertsitsantibacterialactivitythroughbinding16SrRNAofthebacterial30Sribosome,preventingbindingofaminoacyl-tRNAtotheribosomalAsite,inhibitingtranslation.Doxycyclinealsoinhibitsmatrixmetalloproteinases(MMPs).Doxycyclinedisplaysslowantimalarialbenefit,inhibitingexpressionoftheapicoplastgenomeandinducinglossoffunctioninparasites.ThiscompoundinhibitsWolbachiaendosymbiontsfromWucheria,inducingsterilizationandinhibitinggrowth.Doxycyclineimprovespulmonaryfunctionandparametersofchronicobstructivepulmonarysyndrome(COPD)inclinicalsettings.Additionally,doxycyclineinhibitsmigrationandproliferationofbreastadenocarcinomacells.Doxycyclinealsoattenuatesthedevelopmentofcardiachypertrophyinvivoanddisplaysanti-allergicandanti-asthmabenefits,suppressingactivationofIgEandupregulatingexpressionofIL-2.

ProductInfo

CasNo.	17086-28-1
Purity	≥97%
Formula	C₂₂H₂₄N₂O₈•H₂O
FormulaWt.	462.45
ChemicalName	[4S-(4α,4aα,5α,5aα,6α,12aα)]-4-(Dimethylamino)-1,-4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-penta-hydroxy-6-methyl-1,11-dioxo-2-naphthacenecarbox-amidemonohydrate
IUPACName	(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate
Synonym	Doxycycline;Jenacyclin;Supracyclin;Vibramycin
MeltingPoint	201°C
Solubility	Solubleinethanol(2mg/mL)ormethanol.
Appearance	YellowCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	D5898MSDSPDF
InfoSheet	D5898InfoSheetPDF

References

JoksR,DurkinHG.Non-antibioticpropertiesoftetracyclinesasanti-allergyandasthmadrugs.PharmacolRes.2011Dec;64(6):602-9.PMID:21501686.

DalviPS,SinghA,TrivediHR,etal.Effectofdoxycyclineinpatientsofmoderatetoseverechronicobstructivepulmonarydiseasewithstablesymptoms.AnnThoracMed.2011Oct;6(4):221-6.PMID:21977068.

ErramiM,GalindoCL,TassaAT,etal.Doxycyclineattenuatesisoproterenol-andtransverseaorticbanding-inducedcardiachypertrophyinmice.JPharmacolExpTher.2008Mar;324(3):1196-203.PMID:18089841.

DahlEL,ShockJL,ShenaiBR,etal.TetracyclinesspecificallytargettheapicoplastofthemalariaparasitePlasmodiumfalciparum.AntimicrobAgentsChemother.2006Sep;50(9):3124-31.PMID:16940111.

HoeraufA,MandS,FischerK,etal.Doxycyclineasanovelstrategyagainstbancroftianfilariasis-depletionofWolbachiaendosymbiontsfromWuchereriabancroftiandstopofMICROFILariaproduction.MedMicrobiolImmunol.2003Nov;192(4):211-6.PMID:12684759.

DursunD,KimMC,SolomonA,etal.Treatmentofrecalcitrantrecurrentcornealerosionswithinhibitorsofmatrixmetalloproteinase-9,doxycyclineandcorticosteroids.AmJOphthalmol.2001Jul;132(1):8-13.PMID:11438047.

FifeRS,SledgeGWJr.Effectsofdoxycyclineoninvitrogrowth,migration,andgelatinaseactivityofbreastcarcinomacells.JLabClinMed.1995Mar;125(3):407-11.PMID:7897308.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂