Efavirenzisanon-nucleosidereversetranscriptaseinhibitor(NNRTI)thatexhibitsantiviralandanticanceractivities.EfavirenzisclinicallyusedtotreatHIVinfection;itinducesautophagyinneurons,leADIngtosomecentrallymediatedtoxicity.Invariouscancercelllines,efavirenzinhibitscellularproliferationandincreasesactivationofp53.
| CasNo. | 154598-52-4 |
|---|---|
| Purity | ≥99% |
| Formula | C14H9ClF3NO2 |
| FormulaWt. | 315.67 |
| IUPACName | (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one |
| MeltingPoint | 139-141°C |
| Solubility | Ethanol(20mg/ml),DMF(20mg/ml),DMSO(14mg/ml) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | E2003MSDSPDF |
|---|---|
| InfoSheet | E2003InfoSheetPDF |
| Brochures | AntiviralsBooklet |
SchauerGD,HuberKD,LeubaSH,etal.MechanismofallostericinhibitionofHIV-1reversetranscriptaserevealedbysingle-moleculeandensemblefluorescence.NucleicAcidsRes.2015Feb1;42(18):11687-96.PMID:25232099.
PurnellPR,FoxHS.Efavirenzinducesneuronalautophagyandmitochondrialalterations.JPharmacolExpTher.2014Nov;351(2):250-8.PMID:25161171.
HechtM,HarrerT,BüttnerM,etal.CytotoxiceffectofefavirenzisselectiveagainstcancercellsandassociatedwiththecannABInoidsystem.AIDS.2013Aug24;27(13):2031-40.PMID:23612009.
