EmtricitABIneisacytidinenucleosideanalogreversetranscriptaseinhibitor(NRTI)thatisclinicallyusedtotreatHIVinfection.ThisantiviralalsodisplayssomeefficacyinthetreatmentofhepatitisBinfection.Emtricitabineistypicallyco-admiNISTeredwithotherantiretrovirals;italsoinhibitstelomeraseactivityinvitro.
| CasNo. | 143491-57-0 |
|---|---|
| Purity | ≥98% |
| Formula | C8H10FN3O3S |
| FormulaWt. | 247.25 |
| IUPACName | 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5178MSDSPDF |
|---|---|
| InfoSheet | E5178InfoSheetPDF |
| Brochures | AntiviralsBooklet |
KulkarniR,HluhanichR,McCollDM,etal.Thecombinedanti-HIV-1activitiesofemtricitabineandtenofovirplustheintegraseinhibitorelvitegravirorraltegravirshowhighlevelsofsynergyinvitro.AntimicrobAgentsChemother.2014Oct;58(10):6145-50.PMID:25092710.
ArribasJR,EronJ.Advancesinantiretroviraltherapy.CurrOpinHIVAIDS.2013Jul;8(4):341-9.PMID:23666392.
LeeansyahE,CameronPU,SolomonA,etal.Inhibitionoftelomeraseactivitybyhumanimmunodeficiencyvirus(HIV)nucleos(t)idereversetranscriptaseinhibitors:apotentialfactorcontributingtoHIV-associatedacceleratedaging.JInfectDis.2013Apr;207(7):1157-65.PMID:23303810.
