Description
EnfuvirtideisasyntheticpeptidederivedfromHIV-1thatexhibitsantiviralactivity.Enfuvirtideinhibitsviralfusion,mimickingtheaminoacidsequenceofgp41,preventingfusionofthevirustothehostcellmembrane.Enfuvirtidemayalsoinduceapoptosisinbystandercells.
References
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CaiL,GochinM,LiuK.BiochemistryandbiophysicsofHIV-1gp41-membraneinteractionsandimplicationsforHIV-1envelopeproteinmediatedviral-cellfusionandfusioninhibitordesign.CurrTopMedChem.2011Dec;11(24):2959-84.PMID:22044229.