Ergosterol is a sterol component of cell membranes in yeast and fungi. Ergosterol is a target for many antifungal compounds. Ergosterol exhibits anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In animal models of bladder cancer, ergosterol inhibits tumor promotion. Ergosterol also inhibits neovascularization and decreases tumor growth in animal models of sarcoma.
| Cas No. | 57-87-4 |
|---|---|
| Purity | ≥96% |
| Formula | C28H44O |
| Formula Wt. | 396.65 |
| Chemical Name | (3β,5α)-Ergostan-3-ol |
| IUPAC Name | (3S,9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Synonym | Ergosterin, Provitamin D2. |
| Melting Point | 168°C |
| Solubility | Practically insoluble in water. Soluble in chloroform, boiling ether, boiling alcohol. |
| Appearance | White or almost white crystalline |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | E6825 MSDS PDF |
|---|---|
| Info Sheet | E6825 Info Sheet PDF |
Roberts CW, McLeod R, Rice DW, et al. Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa. Mol Biochem Parasitol. 2003 Feb;126(2):129-42. PMID: 12615312.
Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001 May;131(5):1409-13. PMID: 11340091.
Yazawa Y, Yokota M, Sugiyama K. Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A. Biol Pharm Bull. 2000 Nov;23(11):1298-302. PMID: 11085355.
