Erythromycinisamacrolideantibioticthatbindsthe50ssubunitofbacterialribosomes,inhibitingproteinsynthesisbypreventingtransferoftRNAfromtheAsitetothePsite.Thiscompounddisplaysantibacterialactivityagainstbothgrampositiveandgramnegativebacteria;italsoinhibitsmammalianmRNAsplicing.
| CasNo. | 114-07-8 |
|---|---|
| Purity | ≥94% |
| Formula | C37H67NO13 |
| FormulaWt. | 733.93 |
| ChemicalName | ErythromycinA |
| IUPACName | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| Synonym | Abomacetin;Aknin;EMU;E-Mycin;Erymax;Erycen;Erycin. |
| MeltingPoint | 135-140°C |
| Solubility | Veryslightlysolubleinwater(~2mg/ml).Freelysolubleinalcohols,acetone,ethylacetate,acetonitrileorchloroform. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | E6994MSDSPDF |
|---|---|
| InfoSheet | E6994InfoSheetPDF |
HertweckM,HillerR,MuellerMW.Inhibitionofnuclearpre-mRNAsplicingbyantibioticsinvitro.EurJBiochem.2002Jan;269(1):175-83.PMID:11784311.
MenningerJR,OttoDP.Erythromycin,carbomycin,andspiramycininhibitproteinsynthesisbystimulatingthedissociationofpeptidyl-tRNAfromribosomes.AntimicrobAgentsChemother.1982May;21(5):811-8.PMID:6179465.
