Finasterideisaninhibitorofsteroid5-α-reductasethatdecreasesmetabolismoftestosterone,decreasingcellproliferationandfluidproductionintheprostate;itisclinicallyusedtotreatbenignprostatichyperplasia(BPH)andmalepatternbaldness.Finasteridealsoexhibitsantifungalandanticancerchemotherapeuticactivities.FinasterideinhibitsgrowthofCandida.Additionally,finasteridesuppressesregrowthofregressedprostatetumorsandinhibitscellproliferationinvivoandinvitroinshorttermapplicationmodels.
| CasNo. | 98319-26-7 |
|---|---|
| Purity | ≥98% |
| Formula | C23H36N2O2 |
| FormulaWt. | 372.54 |
| ChemicalName | (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide |
| IUPACName | (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide |
| Synonym | Finastid;Propecia;Proscar;Prostide |
| MeltingPoint | 252-254°C°r257°C |
| Solubility | Solubleinchloroform.DMSO,ethanolandmethanol.Slighlysolubleinwater. |
| Appearance | White/off-whiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F3354MSDSPDF |
|---|---|
| InfoSheet | F3354InfoSheetPDF |
Chavez-DozalAA,LownL,JahngM,etal.AninvitroanalysisoffinasterideactivityagainstCandidaalbicansurinarybiofilmformationandfilamentation.AntimicrobAgentsChemother.2014Jul21.[Epubaheadofprint].PMID:25049253.
MasoodiKZ,RamosGarciaR,PascalLE,etal.5α-reductaseinhibitionsuppressestestosterone-inducedinitialregrowthofregressedxenograftprostatetumorsinanimalmodels.Endocrinology.2013Jul;154(7):2296-307.PMID:23671262.
ZagerMG,BartonHA.Amultiscale,mechanism-driven,dynamicmodelfortheeffectsof5α-reductaseinhibitiononprostatemaintenance.PLoSOne.2012;7(9):e44359.PMID:22970204.
