Fleroxacinisafluoroquinoloneantibioticthatdisplaysantibacterialactivityagainstgrampositiveandgramnegativebacteria.FleroxacininhibitsbacterialDNAgyraseandhelicase.Invitro,fleroxacininhibitsDNAunwindingandATPaseactivitiesofBloomhelicase,stABIlizingtheenzymeinalowactivityconformation,disruptingATPhydrolysisandblockinghelicasetranslocationonDNAstrands.Additionally,fleroxacinincreasesreactiveoxygenspecies(ROS)andperoxidationofsqualenewhenexposedtoUVAlight,indicatingphototoxicityinvitro.
| CasNo. | 79660-72-3 |
|---|---|
| Purity | ≥98% |
| Formula | C17H18F3N3O3 |
| FormulaWt. | 369.34 |
| ChemicalName | AM-833;Megalocin;Megalone;Quinodis |
| IUPACName | 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylicacid |
| Synonym | AM-833;Megalocin;Megalone;Quinodis |
| MeltingPoint | 264-266°C |
| Solubility | Solubleinacid,alkali,notsolubleinwater |
| Appearance | WhitePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4518MSDSPDF |
|---|---|
| InfoSheet | F4518InfoSheetPDF |
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GockeE.Mechanismofquinolonemutagenicityinbacteria.MutatRes.1991May;248(1):135-43.PMID:1851537.
